Since you have experience with ANSI C and Python, you might find that continuing in a similar vein could be easiest. Node-RED, with its graphical flow-based programming model, can indeed make coding more visual and intuitive, especially for integrating different hardware components like your Temp-Hum 4 Click Board.
And if you’re looking to develop from scratch, consider using your existing coding skills to create custom scripts that interface directly with your hardware.
This approach can give you more control and flexibility over your project.